Care that makes sense for you.

No blame. No rushing. No judgement.
Just thoughtful partnership and medicine built around you.

The Detailsappointments for prospective patients

How Grace Works

We Listen First

Your story, symptoms, history, stress, sleep, nutrition, and what you've already tried all matter. We start by understanding what has been happening, not by jumping to a protocol.

We Look Deeper

When it makes sense, we use targeted labs, genetics, hormone or metabolic testing, and osteopathic evaluation to gather more information.

We Support Thoughtfully

Care is tailored to what we learn about you. That might include nutrition, supplements, lifestyle changes, nervous-system support, osteopathic treatment, or simply deciding what doesn't need intervention.

What brings people to Grace?

Persistent or unexplained fatigue

Chronic pain and musculoskeletal concerns

Digestive symptoms and food reactions

Hormone balance and midlife changes

Brain fog, headaches, and difficulty concentrating

Sleep challenges

Histamine and inflammatory symptoms

Metabolic health and blood sugar concerns

Stress and nervous-system dysregulation

Complex symptoms that don't fit neatly into one box

Genetics, nutrients and personalized health planning

Staying strong, capable and healthy as you age

Understanding the "Why" Beneath Your Symptoms

At Grace, your symptoms aren't random. They can reflect patterns in how different systems in your body are working together.

Dr. Melissa uses your story alongside genetics, labs, and systems biology to look at how things like inflammation, hormone signaling, nutrient needs, neurotransmitters, metabolism, and stress response may be interacting.

Rather than focusing on a single gene, symptom, or isolated lab value, we look at the bigger picture and ask what might help explain why your body is responding the way it is.

Genetic insights can add another piece, helping us recognize places where your body may be more vulnerable and why an approach that works beautifully for one person may not be right for another.

This isn't about collecting labels. It's about making care more thoughtful and personal.

programs at grace

Aging Gracefully

A four-month physician-guided active aging program designed to help you understand where you are now, what deserves your attention, and where your effort is best spent.

Explore Aging Gracefully → Coming Soon

Wondering if Grace might be right for you?

Learn more about how care works, what to expect, and the different ways to begin.

See How Grace Works

Address

4606 Moorefield Memorial Highway

Pickens, SC 29671

with Willow Retreat Wellness Center

Hours

Monday: 9am to 6pm

Tuesday: 1pm to 6pm

Thursday: 9am to 5pm

What Patients Say...

Testimonials Sliders Preview

A Steady Partner Through Complex Care

" Dr. Melissa is compassionate, intelligent and creative. She is fiercely persistent when it comes to getting to the root of a problem and finding solutions. She truly cares about her patients and treats the whole person. My case has been extremely complicated. In the midst of the many visits with all of the different “ologists“, Dr. Melissa has been the one constant. Her support and encouragement have been invaluable. Her insight and recommendations have helped me to continue to stand (literally) at the amazement of other practitioners. I am forever grateful for all of her care!"

Client
Charlotte, NC

Looking Beyond the Obvious

" [Dr. Melissa]...does the research and thinks outside the box to get the best results for her patients. She’s wonderful and I highly recommend collaborating with her for better health!"

Client
Anderson, SC

Care Built Around You

" Dr. Melissa is a wonderful and caring doctor!! She spends quality one on one time with me to discuss my health and wellness goals. She provides solutions based on my specific needs to help me achieve my goals. Dr. Melissa keeps in touch periodically to check on my progress making any necessary adjustments if needed."

Client
Piedmont, SC

Care That Takes Time

"She takes the time to listen, is supportive & truly wants to help. If you hate modern assembly line “health care” you will love Dr. Melissa."

Client
Easley, SC

Knowledgeable, Thoughtful Care

" Dr. Overman is an excellent and empathetic listener.... She is extraordinarily knowledgeable about the biochemical pathways of the body, and uses epigenetics as a way to determine root causes for different health issues. I would highly recommend Dr. Melissa Overman to any of my friends or family."

Client
Greenville, SC

Care That Starts With Your Goals

"Dr. Melissa starts with my goals and brings her expertise in epigenetics and natural supplements to support my health, rather than react to disease."

Client
Seneca, SC

Hey there!

I'm Dr. Melissa Overman

When I started Grace Integrative Medicine in 2018, I was frustrated by a pattern I kept seeing in medicine: people blamed when their bodies didn't respond the way they were expected to.

But human bodies aren't algorithms. We don't all respond the same way, and I believe good care starts with being curious about why.

That's why it's called Grace. When something doesn't go as planned, we adjust. We look more closely. We keep learning.

I'm an osteopathic physician, board-certified in Preventive Medicine and fellowship-trained in Integrative Medicine. My work brings together your story, systems biology, genetics, structural medicine, and what we can learn from the way your body responds.

I don't pretend to have every answer. But I will listen, think deeply, research thoroughly, and collaborate honestly. And if someone else is better positioned to help you, I'll help you find them.

In the foothills of the blue ridge

Grace in Pickens, South Carolina

Grace Integrative Medicine is proud to call Pickens home. After more than 20 years living and working in the Upstate and more than seven years serving patients through Grace, Dr. Melissa believes good care grows through relationships built over time.

Located at Willow Retreat Wellness Center, Grace is part of a collaborative community focused on whole-person health and well-being.

Grace also reaches beyond the exam room through community education, small-group gatherings, and local events.

In-person care is available in Pickens, with virtual visits available across North and South Carolina.

Small community gatherings

Everyday Grace

Everyday Grace brings small, thoughtful conversations about health and our bodies to Grace Integrative Medicine.

Led by Dr. Melissa Overman, these monthly gatherings explore topics like sleep, hormones, nutrition, genetics, stress, metabolism, supplements, lab results, and the questions that come up when you’re trying to understand your health.

There are no lectures and no expectation that you arrive knowing the right questions to ask. Bring your curiosity, your experience, and whatever has you wondering.

Everyday Grace is free and offered monthly, both in person at Grace and virtually.

Learn more about Everyday Grace →